(±)-雌馬酚抑制劑Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora.?The estrogen receptor (ER) agonist activity of the naturally occurring (S)-enantiomer (EC50?= 85 and 65 nM for human ERα and ERβ, respectively) is similar to that of genistein but exceeds that of daidzein.?(S)-Equol preferentially binds ERβ (Ki?= 0.73 nM) and demonstrates approximately 9-fold lower affinity for ERα (Ki?= 6.41 nM).?(S)-equol is also a potent antagonist of dihydrotestosterone, which has important implications for prostate cancer and other androgen-mediated pathologies.
